Content (Syllabus outline)

Regulation of gene expression in eucaryotes: review of transcritional regulation, yeast gal-system, dynamic chromatin, short-term and long-term activation of genes in a chromatin environment, gender-specific silencing of genes and chromosomes, post-transcriptional gene repression by miRNA.  Genetic basis of ontogenetic development, the development plan and the formation of complex patterns, cell differentiation. Development parallels between vertebrates and insects, genetic sex determination, genetic interpretation of the formation of developmental patterns.

Genomics: genomic sequences, genomic maps, identification of specific genes, bioinformatics and functional genomics base. Mobile genetic elements and their role. Changes in genetic material: mutations, repair and mejotic recombination, chromosome aberrations. The importance of genetic variation: population genetics, genetic variability and its changes, the effect of sexual reproduction, genetic sources of variation, selection. Genetics ofquantitative traits and basic statistical methods, distribution of genotypes andphenotypes, reaction norm, from genetic and share. Evolutionary genetics:Variation and diversity of populations, adaptation, genetic aspect of variation between and within populations, speciation, the origin of new genes, molecular evolution, the existence of a common ancestry, comparative genomics.

Prerequisites

Requirements for enrolment:

Immatriculation in the current year, knowledge of Genetics and Biochemistry

 Terms of Prerequisites:

Examination of experimental practice: attending tutorials

Examination: presentation of seminar papers