Content (Syllabus outline)
Practical aspects of genomic information, an overview of genome analysis in some species, a comparative analysis of genomic information. Techniques and potential applications of transgenesis in animals. The importance of homologous recombination for targeted intervention in the genome, knock-out technology, constitutive and conditional elimination of genes, molecular markers and their use for gene mapping and characterization of populations. Techniques and potential use of animal cloning. Development of totipotent cell lines, embryonic stem cell technology and and production chimeras. Breeding transgenic animals, biotechnological manipulation of the digestive tract microflora. In vitro expression systems. Transgenic animals for studies of resistance, as models for studying diseases and therapeutic options (xenotransplantation). "Gene pharming" andapplications in the pharmaceutical industry. Transgenesis in animal production. Animal models for studying host-pathogen interactions. The use of molecular markers in selection of farm animals (MAS) and the evaluation of animal genetic resources and their management. QTL - concept and applications, the concept of candidate genes, association studies and physical cloning of candidate regions in the animal genome.
Requirements for enrolment:
Immatriculation in the current year and knowledge in Genetics 1 and Genetics 2
Terms of Prerequisites:
Examination of experimental practice: attending tutorials
Examination: presentation of seminar paper